Interleukin 18 (IL18) gene promoter polymorphisms are associated with type 1 diabetes mellitus in Brazilian patients

Interleukin 18 promoter polymorphisms are not strongly associated with type 1 diabetes in a UK population

Interleukin-18 Promoter Gene Polymorphisms are not Associated with Myocardial Infarction in Type 2 Diabetes in Slovenia

Type 2 diabetes is a major risk factor for myocardial infarction (MI) and chronic inflammation may play a central role in both diseases. Interleukin (IL)-18 is a potent proinflammatory cytokine, which is considered important in acute coronary syndromes and type 2 diabetes. We investigated the association of the -137 (G>C), polymorphism (rs187238) and the -607 (C>A) polymorphism (rs1946518) of t...

CTLA4 promoter polymorphisms are associated with canine diabetes mellitus.

Canine diabetes mellitus (DM) shares many similarities with human type 1 diabetes (T1D). It is a complex genetic disorder, which shows marked differences in breed susceptibility, with Samoyed dogs being highly susceptible, whereas the Boxer breed is relatively resistant. A number of immune response genes, which have been associated with human T1D, have also been implicated in determining suscep...

Vitamin D gene polymorphisms are associated with type 1 diabetes mellitus in Korean youth

Vitamin D deficiency is reported in patients with type 1 diabetes mellitus (T1DM). Allelic variations in the gene associated with vitamin D metabolism were reported to play a role in glucose metabolism. CYP2R1 and CYP27B1 gene polymorphisms were investigated as a candidate gene for T1DM in Korean youth. We measured serum level of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in 217 subjects a...

Brief Genetics Report Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes

Type 1 diabetes is believed to be a Th1 lymphocyte– mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of -interferon production. The aim of our study was to evaluate the frequency of...